Overview
Open Interventions → Pulmonary vasodilators. Choose Off, Low, Medium, High. Effect levels and flow targets represent illustrative modeled responses; they are not clinical dose instructions.
An endothelin receptor antagonist such as macitentan or ambrisentan reduces endothelin-mediated constrictor/growth signaling. The simulator uses one representative class response; individual agents are not interchangeable dose-for-dose.
The paused reference covers the route (Oral maintenance treatment after initiation and titration.), example doses/settings, indications, adverse effects, contraindications/precautions and monitoring. These details are available after the intervention is selected.
What to monitor in the reference: Blood pressure, oedema/weight, haemoglobin, pregnancy prevention/testing and agent-specific liver/renal monitoring; reassess symptoms, RV function and risk.