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The Lab

How the model works

Heart sounds, clicks, snaps & splitting

Sound markers are illustrative valve-event annotations with pressure-dependent timing.

Overview

The Wiggers sound layer marks M1/T1 and A2/P2 components, ejection clicks, prolapse clicks, opening snaps and selected gallops/knock. The overlay can also draw an original synthesized cardiophonogram (PCG) from these timings; neither display is a patient recording or a complete acoustic simulation.

A marker assumes the relevant audible phenotype. For example, an ejection click or opening snap assumes sufficiently mobile leaflets; severely calcified immobile valves may not produce that sound clinically.

Cardiophonogram in the overlay

Select PCG in Hemodynamic Overlay for a separate bottom lane with relative amplitude. It shares the pressure/ECG clock, hover/touch inspection and main pause control. Its fixed scale cannot alter the pressure axis.

Short damped oscillations depict the existing M1/T1, A2/P2, clicks, snaps and selected S3/S4/knock. Event phases use pressure-derived valve opening/closure. Positive pressure gradients gate selected valve murmurs, with delayed onset for the prolapse example. Relative amplitude is bounded and does not grade a lesion; a quiet signal does not exclude severe disease.

The synthetic frequencies are approximately 30 Hz for low-frequency gallops, 70 Hz for closure components and 105 Hz for clicks. A 600 Hz drawing lattice resolves these bursts without altering the 250 Hz pressure lattice. Sound-event histories are tied to each mechanical beat’s start and duration, so crossing a beat boundary, scrolling or revisiting a paused time cannot reuse another beat’s sound times. No audio recording, microphone response, chest transmission, prosthetic acoustic signature or comprehensive shunt-murmur model is supplied. VF, ventricular pauses and absent native flow do not receive an organized acoustic cycle.

S1 and S2 splitting

S1 separates mitral and tricuspid closure by a short reference interval, widened in the selected RBBB example. S2 follows A2/P2 timing with ordinary inspiratory widening, wider splitting in selected RBBB/PS examples, and reversed/paradoxical ordering with delayed LV ejection in selected left-sided conduction/outflow states.

Large ASD has a fixed-splitting example; PAPVR alone does not inherit it. Pulmonary hypertension uses an accentuated P2 and a selected narrow split rather than assuming fixed splitting in every patient. Positive-pressure ventilation does not blindly apply spontaneous inspiratory rules.

Opening snap and clicks

The opening-snap delay uses LA pressure and LV systolic pressure: 0.15 − 0.004 × (LA pressure − 3) + 0.0002 × (LV systolic pressure − 120), bounded to 0.045–0.14 seconds. This is a synthetic timing relation, not a valve-area equation. Transmitted external pressure is excluded from its filling interpretation.

Ejection clicks track the relevant pressure-dependent opening event. The MVP click shifts with loading/prolapse factor rather than grade alone. Very short cardiac cycles compress some timing to fit available diastole; the tooltip identifies that limitation.

Gallops and knock

A congested selected myocardial/regurgitant phenotype can add S3. S4 requires an organized atrial contraction and a compatible stiff-ventricle phenotype, so AF does not receive a normal S4. Constriction can add an early diastolic knock. Marker presence and amplitude are teaching assumptions, not diagnostic sensitivity or specificity.

References & further reading

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